I'm finally getting a chance to do some work with Guice 2.0. I don't know if I just couldn't wrap my head around Guice in the past and I've finally "gotten" it, or if Guice 2.0 provides a more approachable API. Either way, I'm finding it great to use.
I've been mildly whiny about Guice in the past, stating that it wasn't completely statically typed (which is true, since it's possible you'll ask for a resource at runtime that isn't available because it wasn't configured). But even with that small limitation, I'm finding Guice 2.0 to be far better than Spring for dependency injection. The code is much smaller, much more type-safe, not XML (a big plus), and much more strongly type-checked.
If you haven't checked out Guice, or if you tried Guice 1.0 but haven't tried out 2.0, you should give 2.0 a serious look.
Now I need to integrate Guice with Jersey (the JAX-RS reference implementation)...